Blockade of the PI-3K signaling pathway by the Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces macrophages to synthesize and secrete pro-inflammatory cytokines

The Aggregatibactor actinomycetemcomitans cytolethal distending toxin (Cdt) induces G2 arrest and apoptosis in lymphocytes; these toxic effects are due to the active subunit, CdtB, which functions as a phosphatidylinositol-3,4,5-triphosphate (PIP3) phosphatase. We now extend our investigation and de...

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Autores principales: Shenker, Bruce J., Walker, Lisa P., Zekavat, Ali, Dlakić, Mensur, Boesze-Battaglia, Kathleen
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4146646/
https://ncbi.nlm.nih.gov/pubmed/24697951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cmi.12299
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