Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells

Enhancing production of the anti-inflammatory cytokine interleukin-10 (IL-10) is a promising strategy to suppress pathogenic inflammation. To identify new mechanisms regulating IL-10 production, we conducted a phenotypic screen for small molecules that enhance IL-10 secretion from activated dendriti...

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Publicado en:Nat Chem Biol
Main Authors: Johannessen, Liv, Sundberg, Thomas B, O’Connell, Daniel J, Kolde, Raivo, Berstler, James, Billings, Katelyn J, Khor, Bernard, Seashore-Ludlow, Brinton, Fassl, Anne, Russell, Caitlin N, Latorre, Isabel J, Jiang, Baishan, Graham, Daniel B, Perez, Jose R, Sicinski, Piotr, Phillips, Andrew J, Schreiber, Stuart L, Gray, Nathanael S, Shamji, Alykhan F, Xavier, Ramnik J
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693369/
https://ncbi.nlm.nih.gov/pubmed/28805801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2458
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