Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function In Vivo

Salt-inducible kinases (SIKs) are promising therapeutic targets for modulating cytokine responses during innate immune activation. The study of SIK inhibition in animal models of disease has been limited by the lack of selective small-molecule probes suitable for modulating SIK function in vivo. We...

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Bibliografske podrobnosti
izdano v:ACS Chem Biol
Main Authors: Sundberg, Thomas B., Liang, Yanke, Wu, Huixian, Choi, Hwan Geun, Kim, Nam Doo, Sim, Taebo, Johannessen, Liv, Petrone, Adam, Khor, Bernard, Graham, Daniel B., Latorre, Isabel J., Phillips, Andrew J., Schreiber, Stuart L., Perez, Jose, Shamji, Alykhan F., Gray, Nathanael S., Xavier, Ramnik J.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992440/
https://ncbi.nlm.nih.gov/pubmed/27224444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00217
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