Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8

[Image: see text] Cortistatin A is a natural product isolated from the marine sponge Corticium simplex and was found to be a potent and selective inhibitor of CDK8. Many synthetic groups have reported total syntheses of Cortistatin A; however, these syntheses require between 16 and 30 steps and repo...

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Bibliografiska uppgifter
I publikationen:ACS Med Chem Lett
Huvudupphovsmän: Hatcher, John M., Wang, Eric S., Johannessen, Liv, Kwiatkowski, Nicholas, Sim, Taebo, Gray, Nathanael S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2018
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004574/
https://ncbi.nlm.nih.gov/pubmed/29937979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00011
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