Structure–Activity Relationships of [des-Arg(7)]Dynorphin A Analogues at the κ Opioid Receptor

Dynorphin A (Dyn A) is an endogenous ligand for the opioid receptors with preference for the κ opioid receptor (KOR), and its structure–activity relationship (SAR) has been extensively studied at the KOR to develop selective potent agonists and antagonists. Numerous SAR studies have revealed that th...

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Publicat a:J Med Chem
Autors principals: Ramos-Colon, Cyf N., Lee, Yeon Sun, Remesic, Michael, Hall, Sara M., LaVigne, Justin, Davis, Peg, Sandweiss, Alexander J., McIntosh, Mary I., Hanson, Jessica, Largent-Milnes, Tally M., Vanderah, Todd W., Streicher, John, Porreca, Frank, Hruby, Victor J.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693303/
https://ncbi.nlm.nih.gov/pubmed/27797517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01411
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