Modification of Amphipathic Non-opioid Dynorphin A Analogues for Rat Brain Bradykinin Receptors

It has been shown that under chronic pain or nerve injury conditions, up-regulated dynorphin A (Dyn A) interacts with bradykinin receptors (BRs) to cause hyperalgesia in the spinal cord. Thus BRs antagonist can modulate hyperalgesia by blocking Dyn A’s interaction with the BRs in the central nervous...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Lee, Yeon Sun, Hall, Sara M., Ramos-Colon, Cyf, Remesic, Michael, LeBaron, Lindsay, Nguyen, Ann, Rankin, David, Porreca, Frank, Lai, Josephine, Hruby, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258438/
https://ncbi.nlm.nih.gov/pubmed/25434001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.11.026
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