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Modification of Amphipathic Non-opioid Dynorphin A Analogues for Rat Brain Bradykinin Receptors

It has been shown that under chronic pain or nerve injury conditions, up-regulated dynorphin A (Dyn A) interacts with bradykinin receptors (BRs) to cause hyperalgesia in the spinal cord. Thus BRs antagonist can modulate hyperalgesia by blocking Dyn A’s interaction with the BRs in the central nervous...

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Dades bibliogràfiques
Publicat a:Bioorg Med Chem Lett
Autors principals: Lee, Yeon Sun, Hall, Sara M., Ramos-Colon, Cyf, Remesic, Michael, LeBaron, Lindsay, Nguyen, Ann, Rankin, David, Porreca, Frank, Lai, Josephine, Hruby, Victor J.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258438/
https://ncbi.nlm.nih.gov/pubmed/25434001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.11.026
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