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Modification of Amphipathic Non-opioid Dynorphin A Analogues for Rat Brain Bradykinin Receptors
It has been shown that under chronic pain or nerve injury conditions, up-regulated dynorphin A (Dyn A) interacts with bradykinin receptors (BRs) to cause hyperalgesia in the spinal cord. Thus BRs antagonist can modulate hyperalgesia by blocking Dyn A’s interaction with the BRs in the central nervous...
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| Publicat a: | Bioorg Med Chem Lett |
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| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4258438/ https://ncbi.nlm.nih.gov/pubmed/25434001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.11.026 |
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