Modification of Amphipathic Non-opioid Dynorphin A Analogues for Rat Brain Bradykinin Receptors

It has been shown that under chronic pain or nerve injury conditions, up-regulated dynorphin A (Dyn A) interacts with bradykinin receptors (BRs) to cause hyperalgesia in the spinal cord. Thus BRs antagonist can modulate hyperalgesia by blocking Dyn A’s interaction with the BRs in the central nervous...

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Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem Lett
Asıl Yazarlar: Lee, Yeon Sun, Hall, Sara M., Ramos-Colon, Cyf, Remesic, Michael, LeBaron, Lindsay, Nguyen, Ann, Rankin, David, Porreca, Frank, Lai, Josephine, Hruby, Victor J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258438/
https://ncbi.nlm.nih.gov/pubmed/25434001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.11.026
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