Cyclic non-opioid dynorphin A analogues for the bradykinin receptors

Nerve injury and inflammation cause up-regulation of an endogenous opioid ligand, dynorphin A (Dyn A), in the spinal cord resulting in hyperalgesia via the interaction with bradykinin receptors (BRs). This is a non-opioid neuroexcitatory effect that cannot be blocked by opioid antagonists. Our syste...

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Publicado en:Bioorg Med Chem Lett
Main Authors: Lee, Yeon Sun, Remesic, Michael, Ramos-Colon, Cyf, Hall, Sara M., Kuzmin, Alexander, Rankin, David, Porreca, Frank, Lai, Josephine, Hruby, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159310/
https://ncbi.nlm.nih.gov/pubmed/27756562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.10.010
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