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Cyclic non-opioid dynorphin A analogues for the bradykinin receptors
Nerve injury and inflammation cause up-regulation of an endogenous opioid ligand, dynorphin A (Dyn A), in the spinal cord resulting in hyperalgesia via the interaction with bradykinin receptors (BRs). This is a non-opioid neuroexcitatory effect that cannot be blocked by opioid antagonists. Our syste...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5159310/ https://ncbi.nlm.nih.gov/pubmed/27756562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.10.010 |
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