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Various modifications of the amphipathic dynorphin A phamacophore for rat brain bradykinin receptors
As a unique endogenous opioid ligand, dynorphin A shows paradoxical neuroexcitatory effects at bradykinin receptors, and the effects are known to be amplified by the upregulation of dynorphin A under chronic pain and inflammatory conditions. In our earlier structure-activity relationship studies, th...
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| 出版年: | Chem Biol Drug Des |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5025351/ https://ncbi.nlm.nih.gov/pubmed/27203574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12789 |
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