Structure-activity relationships of non-opioid [des-Arg(7)]-dynorphin A analogues for bradykinin receptors

In our earlier studies, bradykinin receptors (BRs) were identified as a potential target for the neuroexcitatory effects of dynorphin A (Dyn A) in the central nervous system (CNS), and [des-Arg(7)]-Dyn A-(4-11) (6) was discovered as a lead ligand to modulate Dyn A-(2-13) induced neuroexcitatory effe...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioorg Med Chem Lett
Main Authors: Lee, Yeon Sun, Rankin, David, Hall, Sara M., Ramos-Colon, Cyf, Ortiz, Jose Juan, Kupp, Robert, Porreca, Frank, Lai, Josephine, Hruby, Victor J.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250343/
https://ncbi.nlm.nih.gov/pubmed/25282551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.09.033
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