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Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain

Dynorphin A (Dyn A) is a unique endogenous ligand that possesses well-known neuroinhibitory effects via opioid receptors with a preference for the kappa receptor but also neuroexcitatory effects, which cause hyperalgesia. We have shown that the neuroexcitatory effects are mediated through bradykinin...

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Detaylı Bibliyografya
Yayımlandı:ACS Chem Neurosci
Asıl Yazarlar: Hall, Sara M., LeBaron, Lindsay, Ramos-Colon, Cyf, Qu, Chaoling, Xie, Jennifer Yanhua, Porreca, Frank, Lai, Josephine, Lee, Yeon Sun, Hruby, Victor J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689068/
https://ncbi.nlm.nih.gov/pubmed/27619237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00258
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