Discovery of Amphipathic Dynorphin A Analogues to Inhibit the Neuroexcitatory Effects of Dynorphin A through Bradykinin Receptors in the Spinal Cord

[Image: see text] We hypothesized that under chronic pain conditions, up-regulated dynorphin A (Dyn A) interacts with bradykinin receptors (BRs) in the spinal cord to promote hyperalgesia through an excitatory effect, which is opposite to the well-known inhibitory effect of opioid receptors. Conside...

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Main Authors: Lee, Yeon Sun, Muthu, Dhanasekaran, Hall, Sara M., Ramos-Colon, Cyf, Rankin, David, Hu, Jackie, Sandweiss, Alexander J., De Felice, Milena, Xie, Jennifer Yanhua, Vanderah, Todd W., Porreca, Frank, Lai, Josephine, Hruby, Victor J.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021566/
https://ncbi.nlm.nih.gov/pubmed/24742335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja501677q
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