Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuroinflammation

In the CNS, microglia are activated in response to injury or infection and in neurodegenerative diseases. The endocytic and cell signaling receptor, LDL receptor-related protein-1 (LRP1), is reported to suppress innate immunity in macrophages and oppose microglial activation. The goal of this study...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Brifault, Coralie, Gilder, Andrew S., Laudati, Emilia, Banki, Michael, Gonias, Steven L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5682976/
https://ncbi.nlm.nih.gov/pubmed/28972143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.798413
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker