The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains

LDL Receptor-related Protein-1 (LRP1) is an endocytic receptor for diverse ligands. In neurons and neuron-like cells, ligand-binding to LRP1 initiates cell-signaling. Herein, we show that in PC12 and N2a neuron-like cells, LRP1 distributes into lipid rafts and non-raft plasma membrane fractions. Whe...

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Detalhes bibliográficos
Publicado no:Mol Cell Neurosci
Main Authors: Laudati, Emilia, Gilder, Andrew S., Lam, Michael S., Misasi, Roberta, Sorice, Maurizio, Gonias, Steven L., Mantuano, Elisabetta
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056852/
https://ncbi.nlm.nih.gov/pubmed/27565578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2016.08.006
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