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LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response
LDL receptor-related protein-1 (LRP1) is an endocytic and cell-signaling receptor. In mice in which LRP1 is deleted in myeloid cells, the response to lipopolysaccharide (LPS) was greatly exacerbated. LRP1 deletion in macrophages in vitro, under the control of tamoxifen-activated Cre-ER(T) fusion pro...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4747752/ https://ncbi.nlm.nih.gov/pubmed/26787872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515480113 |
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