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Tissue-type plasminogen activator regulates macrophage activation and innate immunity

Tissue-type plasminogen activator (tPA) is the major intravascular activator of fibrinolysis and a ligand for receptors involved in cell signaling. In cultured macrophages, tPA inhibits the response to lipopolysaccharide (LPS) by a pathway that apparently requires low-density lipoprotein receptor-re...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Mantuano, Elisabetta, Azmoon, Pardis, Brifault, Coralie, Banki, Michael A., Gilder, Andrew S., Campana, Wendy M., Gonias, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600142/
https://ncbi.nlm.nih.gov/pubmed/28684538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-04-780205
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