Tissue-type plasminogen activator selectively inhibits multiple toll-like receptors in CSF-1-differentiated macrophages

Tissue-type plasminogen activator (tPA) is a major activator of fibrinolysis, which also attenuates the pro-inflammatory activity of lipopolysaccharide (LPS) in bone marrow-derived macrophages (BMDMs) and in vivo in mice. The activity of tPA as an LPS response modifier is independent of its proteina...

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Publicado en:PLoS One
Autores principales: Das, Lipsa, Azmoon, Pardis, Banki, Michael A., Mantuano, Elisabetta, Gonias, Steven L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6837328/
https://ncbi.nlm.nih.gov/pubmed/31697716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0224738
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