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Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuroinflammation
In the CNS, microglia are activated in response to injury or infection and in neurodegenerative diseases. The endocytic and cell signaling receptor, LDL receptor-related protein-1 (LRP1), is reported to suppress innate immunity in macrophages and oppose microglial activation. The goal of this study...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5682976/ https://ncbi.nlm.nih.gov/pubmed/28972143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.798413 |
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