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A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase

[Image: see text] Human nonlysosomal glucosylceramidase (GBA2) is one of several enzymes that controls levels of glycolipids and whose activity is linked to several human disease states. There is a major need to design or discover selective GBA2 inhibitors both as chemical tools and as potential the...

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Pubblicato in:J Am Chem Soc
Autori principali: Lahav, Daniël, Liu, Bing, van den Berg, Richard J. B. H. N., van den Nieuwendijk, Adrianus M. C. H., Wennekes, Tom, Ghisaidoobe, Amar T., Breen, Imogen, Ferraz, Maria J., Kuo, Chi-Lin, Wu, Liang, Geurink, Paul P., Ovaa, Huib, van der Marel, Gijsbert A., van der Stelt, Mario, Boot, Rolf G., Davies, Gideon J., Aerts, Johannes M. F. G., Overkleeft, Herman S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2017
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5677758/
https://ncbi.nlm.nih.gov/pubmed/28937220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b07352
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