Assessment of Partially Deoxygenated Deoxynojirimycin Derivatives as Glucosylceramide Synthase Inhibitors

[Image: see text] Glucosylceramide synthase (GCS) is an approved drug target for the treatment of Gaucher disease and is considered as a valid target for combating other human pathologies, including type 2 diabetes. The clinical drug N-butyldeoxynojirimycin (Zavesca) is thought to inhibit through mi...

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Main Authors: van den Berg, Richard J. B. H. N., Wennekes, Tom, Ghisaidoobe, Amar, Donker-Koopman, Wilma E., Strijland, Anneke, Boot, Rolf G., van der Marel, Gijsbert A., Aerts, Johannes M. F. G., Overkleeft, Herman S.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2011
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018170/
https://ncbi.nlm.nih.gov/pubmed/24900342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200050s
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