Pharmacological Inhibition of Glucosylceramide Synthase Enhances Insulin Sensitivity

A growing body of evidence implicates ceramide and/or its glycosphingolipid metabolites in the pathogenesis of insulin resistance. We have developed a highly specific small molecule inhibitor of glucosylceramide synthase, an enzyme that catalyzes a necessary step in the conversion of ceramide to gly...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Aerts, Johannes M., Ottenhoff, Roelof, Powlson, Andrew S., Grefhorst, Aldo, van Eijk, Marco, Dubbelhuis, Peter F., Aten, Jan, Kuipers, Folkert, Serlie, Mireille J., Wennekes, Tom, Sethi, Jaswinder K., O’Rahilly, Stephen, Overkleeft, Hermen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298701/
https://ncbi.nlm.nih.gov/pubmed/17287460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db06-1619
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