Pharmacological Inhibition of Glucosylceramide Synthase Enhances Insulin Sensitivity

A growing body of evidence implicates ceramide and/or its glycosphingolipid metabolites in the pathogenesis of insulin resistance. We have developed a highly specific small molecule inhibitor of glucosylceramide synthase, an enzyme that catalyzes a necessary step in the conversion of ceramide to gly...

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Publié dans:Diabetes
Auteurs principaux: Aerts, Johannes M., Ottenhoff, Roelof, Powlson, Andrew S., Grefhorst, Aldo, van Eijk, Marco, Dubbelhuis, Peter F., Aten, Jan, Kuipers, Folkert, Serlie, Mireille J., Wennekes, Tom, Sethi, Jaswinder K., O’Rahilly, Stephen, Overkleeft, Hermen S.
Format: Artigo
Langue:Inglês
Publié: 2007
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298701/
https://ncbi.nlm.nih.gov/pubmed/17287460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db06-1619
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