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Pharmacological Inhibition of Glucosylceramide Synthase Enhances Insulin Sensitivity
A growing body of evidence implicates ceramide and/or its glycosphingolipid metabolites in the pathogenesis of insulin resistance. We have developed a highly specific small molecule inhibitor of glucosylceramide synthase, an enzyme that catalyzes a necessary step in the conversion of ceramide to gly...
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| Gepubliceerd in: | Diabetes |
|---|---|
| Hoofdauteurs: | , , , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2007
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4298701/ https://ncbi.nlm.nih.gov/pubmed/17287460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db06-1619 |
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