Complex formation of sphingomyelin synthase 1 with glucosylceramide synthase increases sphingomyelin and decreases glucosylceramide levels

Sphingolipids, including sphingomyelin (SM) and glucosylceramide (GlcCer), are generated by the addition of a polar head group to ceramide (Cer). Sphingomyelin synthase 1 (SMS1) and glucosylceramide synthase (GCS) are key enzymes that catalyze the conversion of Cer to SM and GlcCer, respectively. Gl...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Hayashi, Yasuhiro, Nemoto-Sasaki, Yoko, Matsumoto, Naoki, Hama, Kotaro, Tanikawa, Takashi, Oka, Saori, Saeki, Tadaaki, Kumasaka, Tatsuya, Koizumi, Takanori, Arai, Seisuke, Wada, Ikuo, Yokoyama, Kazuaki, Sugiura, Takayuki, Yamashita, Atsushi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Lipids
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231140/
https://ncbi.nlm.nih.gov/pubmed/30242129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002048
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