Direct Stereoselective Aziridination of Cyclohexenols with 3‐Amino‐2‐(trifluoromethyl)quinazolin‐4(3H)‐one in the Synthesis of Cyclitol Aziridine Glycosidase Inhibitors

Cyclophellitol aziridine and its configurational and functional isomers are powerful covalent inhibitors of retaining glycosidases, and find application in fundamental studies on glycosidases, amongst others in relation to inherited lysosomal storage disorders caused by glycosidase malfunctioning. F...

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Detalhes bibliográficos
Publicado no:European J Org Chem
Main Authors: Artola, Marta, Wouters, Shirley, Schröder, Sybrin P., de Boer, Casper, Chen, Yurong, Petracca, Rita, van den Nieuwendijk, Adrianus M. C. H., Aerts, Johannes M. F. G., van der Marel, Gijsbert A., Codée, Jeroen D. C., Overkleeft, Herman S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876648/
https://ncbi.nlm.nih.gov/pubmed/31787842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejoc.201801703
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