Direct Stereoselective Aziridination of Cyclohexenols with 3‐Amino‐2‐(trifluoromethyl)quinazolin‐4(3H)‐one in the Synthesis of Cyclitol Aziridine Glycosidase Inhibitors

Cyclophellitol aziridine and its configurational and functional isomers are powerful covalent inhibitors of retaining glycosidases, and find application in fundamental studies on glycosidases, amongst others in relation to inherited lysosomal storage disorders caused by glycosidase malfunctioning. F...

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Bibliografske podrobnosti
izdano v:European J Org Chem
Main Authors: Artola, Marta, Wouters, Shirley, Schröder, Sybrin P., de Boer, Casper, Chen, Yurong, Petracca, Rita, van den Nieuwendijk, Adrianus M. C. H., Aerts, Johannes M. F. G., van der Marel, Gijsbert A., Codée, Jeroen D. C., Overkleeft, Herman S.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Full Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876648/
https://ncbi.nlm.nih.gov/pubmed/31787842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejoc.201801703
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