Distinguishing the differences in β-glycosylceramidase folds, dynamics, and actions informs therapeutic uses

Por Ben Bdira, Fredj, Artola, Marta, Overkleeft, Herman S., Ubbink, Marcellus, Aerts, Johannes M. F. G.
Publicado no J Lipid Res (2018)

Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish

Por Artola, Marta, Kuo, Chi-Lin, Lelieveld, Lindsey T., Rowland, Rhianna J., van der Marel, Gijsbert A., Codée, Jeroen D. C., Boot, Rolf G., Davies, Gideon J., Aerts, Johannes M. F. G., Overkleeft, Herman S.
Publicado no J Am Chem Soc (2019)

Gluco-1H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor

Por Schröder, Sybrin P., Wu, Liang, Artola, Marta, Hansen, Thomas, Offen, Wendy A., Ferraz, Maria J., Li, Kah-Yee, Aerts, Johannes M. F. G., van der Marel, Gijsbert A., Codée, Jeroen D. C., Davies, Gideon J., Overkleeft, Herman S.
Publicado no J Am Chem Soc (2018)

The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors

Por Artola, Marta, Ruíz-Avila, Laura B., Ramírez-Aportela, Erney, Martínez, R. Fernando, Araujo-Bazán, Lidia, Vázquez-Villa, Henar, Martín-Fontecha, Mar, Oliva, María A., Martín-Galiano, A. Javier, Chacón, Pablo, López-Rodríguez, María L., Andreu, José M., Huecas, Sonia
Publicado no Chem Sci (2017)

1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor

Por Artola, Marta, Wu, Liang, Ferraz, Maria J., Kuo, Chi-Lin, Raich, Lluís, Breen, Imogen Z., Offen, Wendy A., Codée, Jeroen D. C., van der Marel, Gijsbert A., Rovira, Carme, Aerts, Johannes M. F. G., Davies, Gideon J., Overkleeft, Herman S.
Publicado no ACS Cent Sci (2017)

Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs

Por Parker, Christopher G., Kuttruff, Christian A., Galmozzi, Andrea, Jørgensen, Lars, Yeh, Chien-Hung, Hermanson, Daniel J., Wang, Yujia, Artola, Marta, McKerrall, Steven J., Josyln, Christopher M., Nørremark, Bjarne, Dünstl, Georg, Felding, Jakob, Saez, Enrique, Baran, Phil S., Cravatt, Benjamin F.
Publicado no ACS Cent Sci (2017)

Nicotiana benthamiana α-galactosidase A1.1 can functionally complement human α-galactosidase A deficiency associated with Fabry disease

Por Kytidou, Kassiani, Beekwilder, Jules, Artola, Marta, van Meel, Eline, Wilbers, Ruud H. P., Moolenaar, Geri F., Goosen, Nora, Ferraz, Maria J., Katzy, Rebecca, Voskamp, Patrick, Florea, Bogdan I., Hokke, Cornelis H., Overkleeft, Herman S., Schots, Arjen, Bosch, Dirk, Pannu, Navraj, Aerts, Johannes M. F. G.
Publicado no J Biol Chem (2018)

New Irreversible α‐l‐Iduronidase Inhibitors and Activity‐Based Probes

Por Artola, Marta, Kuo, Chi‐Lin, McMahon, Stephen A., Oehler, Verena, Hansen, Thomas, van der Lienden, Martijn, He, Xu, van den Elst, Hans, Florea, Bogdan I., Kermode, Allison R., van der Marel, Gijsbert A., Gloster, Tracey M., Codée, Jeroen D. C., Overkleeft, Herman S., Aerts, Johannes M. F. G.
Publicado no Chemistry (2018)

Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors

Por Beenakker, Thomas J. M., Wander, Dennis P. A., Offen, Wendy A., Artola, Marta, Raich, Lluís, Ferraz, Maria J., Li, Kah-Yee, Houben, Judith H. P. M., van Rijssel, Erwin R., Hansen, Thomas, van der Marel, Gijsbert A., Codée, Jeroen D. C., Aerts, Johannes M. F. G., Rovira, Carme, Davies, Gideon J., Overkleeft, Herman S.
Publicado no J Am Chem Soc (2017)