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Distinguishing the differences in β-glycosylceramidase folds, dynamics, and actions informs therapeutic uses

Glycosyl hydrolases (GHs) are carbohydrate-active enzymes that hydrolyze a specific β-glycosidic bond in glycoconjugate substrates; β-glucosidases degrade glucosylceramide, a ubiquitous glycosphingolipid. GHs are grouped into structurally similar families that themselves can be grouped into clans. G...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Ben Bdira, Fredj, Artola, Marta, Overkleeft, Herman S., Ubbink, Marcellus, Aerts, Johannes M. F. G.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277158/
https://ncbi.nlm.nih.gov/pubmed/30279220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.R086629
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