Gluco-1H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor

[Image: see text] Gluco-azoles competitively inhibit glucosidases by transition-state mimicry and their ability to interact with catalytic acid residues in glucosidase active sites. We noted that no azole-type inhibitors described, to date, possess a protic nitrogen characteristic for 1H-imidazoles....

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Schröder, Sybrin P., Wu, Liang, Artola, Marta, Hansen, Thomas, Offen, Wendy A., Ferraz, Maria J., Li, Kah-Yee, Aerts, Johannes M. F. G., van der Marel, Gijsbert A., Codée, Jeroen D. C., Davies, Gideon J., Overkleeft, Herman S.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942873/
https://ncbi.nlm.nih.gov/pubmed/29601200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b02399
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