Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors

[Image: see text] The conformational analysis of glycosidases affords a route to their specific inhibition through transition-state mimicry. Inspired by the rapid reaction rates of cyclophellitol and cyclophellitol aziridine—both covalent retaining β-glucosidase inhibitors—we postulated that the cor...

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Udgivet i:J Am Chem Soc
Main Authors: Beenakker, Thomas J. M., Wander, Dennis P. A., Offen, Wendy A., Artola, Marta, Raich, Lluís, Ferraz, Maria J., Li, Kah-Yee, Houben, Judith H. P. M., van Rijssel, Erwin R., Hansen, Thomas, van der Marel, Gijsbert A., Codée, Jeroen D. C., Aerts, Johannes M. F. G., Rovira, Carme, Davies, Gideon J., Overkleeft, Herman S.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437670/
https://ncbi.nlm.nih.gov/pubmed/28463498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b01773
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