Loss of p300 Accelerates MDS-associated Leukemogenesis

The role that changes in DNA methylation and histone modifications play in human malignancies is poorly understood. p300 and CBP, two distinct but highly homologous lysine acetyltransferases (KATs), are mutated in several cancers, suggesting their role as tumor suppressors. In the current study, we...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Cheng, Guoyan, Liu, Fan, Asai, Takashi, Lai, Fan, Man, Na, Xu, Haiming, Chen, Shi, Greenblatt, Sarah, Hamard, Pierre-Jacques, Ando, Koji, Martinez, Conception, Tadi, Madhavi, Wang, Lan, Xu, Mingjiang, Yang, Feng-Chun, Shiekhattar, Ramin, Nimer, Stephen D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667352/
https://ncbi.nlm.nih.gov/pubmed/27881875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.347
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