CARM1 is essential for myeloid leukemogenesis but dispensable for normal hematopoiesis

Chromatin modifying enzymes, and specifically the protein arginine methyltransferases (PRMTs) have emerged as important targets in cancer. Here, we investigated the role of CARM1 in normal and malignant hematopoiesis. Using conditional knockout mice, we show that loss of CARM1 has little effect on n...

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Publicat a:Cancer Cell
Autors principals: Greenblatt, Sarah M., Man, Na, Hamard, Pierre-Jacques, Asai, Takashi, Karl, Daniel, Martinez, Concepcion, Bilbao, Daniel, Stathais, Vasileios, McGrew-Jermacowicz, Anna, Duffort, Stephanie, Tadi, Madhavi, Blumenthal, Ezra, Newman, Samantha, Vu, Ly, Xu, Ye, Liu, Fan, Schurer, Stephan C., McCabe, Michael T., Kruger, Ryan G., Xu, Mingjiang, Yang, Feng-Chun, Tenen, Daniel, Watts, Justin, Vega, Francisco, Nimer, Stephen D.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6191185/
https://ncbi.nlm.nih.gov/pubmed/29894694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.05.007
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