CARM1 is essential for myeloid leukemogenesis but dispensable for normal hematopoiesis

Chromatin modifying enzymes, and specifically the protein arginine methyltransferases (PRMTs) have emerged as important targets in cancer. Here, we investigated the role of CARM1 in normal and malignant hematopoiesis. Using conditional knockout mice, we show that loss of CARM1 has little effect on n...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Greenblatt, Sarah M., Man, Na, Hamard, Pierre-Jacques, Asai, Takashi, Karl, Daniel, Martinez, Concepcion, Bilbao, Daniel, Stathais, Vasileios, McGrew-Jermacowicz, Anna, Duffort, Stephanie, Tadi, Madhavi, Blumenthal, Ezra, Newman, Samantha, Vu, Ly, Xu, Ye, Liu, Fan, Schurer, Stephan C., McCabe, Michael T., Kruger, Ryan G., Xu, Mingjiang, Yang, Feng-Chun, Tenen, Daniel, Watts, Justin, Vega, Francisco, Nimer, Stephen D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6191185/
https://ncbi.nlm.nih.gov/pubmed/29894694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.05.007
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