Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis

Epigenetic regulators play critical roles in normal hematopoiesis, and the activity of these enzymes is frequently altered in hematopoietic cancers. The major type II protein arginine methyltransferase PRMT5 catalyzes the formation of symmetric dimethyl arginine and has been implicated in various ce...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Liu, Fan, Cheng, Guoyan, Hamard, Pierre-Jacques, Greenblatt, Sarah, Wang, Lan, Man, Na, Perna, Fabiana, Xu, Haiming, Tadi, Madhavi, Luciani, Luisa, Nimer, Stephen D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588241/
https://ncbi.nlm.nih.gov/pubmed/26258414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81749
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