Caspase-3 controls AML1-ETO–driven leukemogenesis via autophagy modulation in a ULK1-dependent manner

AML1-ETO (AE), a fusion oncoprotein generated by t(8;21), can trigger acute myeloid leukemia (AML) in collaboration with mutations including c-Kit, ASXL1/2, FLT3, N-RAS, and K-RAS. Caspase-3, a key executor among its family, plays multiple roles in cellular processes, including hematopoietic develop...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Man, Na, Tan, Yurong, Sun, Xiao-Jian, Liu, Fan, Cheng, Guoyan, Greenblatt, Sarah M., Martinez, Camilo, Karl, Daniel L., Ando, Koji, Sun, Ming, Hou, Dan, Chen, Bingyi, Xu, Mingjiang, Yang, Feng-Chun, Chen, Zhu, Chen, Saijuan, Nimer, Stephen D., Wang, Lan
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2017
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437826/
https://ncbi.nlm.nih.gov/pubmed/28381396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-10-745034
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