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Direct, enantioselective α-alkylation of aldehydes using simple olefins

Although the α-alkylation of ketones has already been established, the analogous reaction using aldehyde substrates has proven surprisingly elusive. Despite the structural similarities between the two classes of compounds, the sensitivity and unique reactivity of the aldehyde functionality has typic...

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Foilsithe in:Nat Chem
Main Authors: Capacci, Andrew G., Malinowski, Justin T., McAlpine, Neil J., Kuhne, Jerome, MacMillan, David W. C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665178/
https://ncbi.nlm.nih.gov/pubmed/29064486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2797
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