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Direct, enantioselective α-alkylation of aldehydes using simple olefins

Although the α-alkylation of ketones has already been established, the analogous reaction using aldehyde substrates has proven surprisingly elusive. Despite the structural similarities between the two classes of compounds, the sensitivity and unique reactivity of the aldehyde functionality has typic...

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Bibliografische gegevens
Gepubliceerd in:Nat Chem
Hoofdauteurs: Capacci, Andrew G., Malinowski, Justin T., McAlpine, Neil J., Kuhne, Jerome, MacMillan, David W. C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665178/
https://ncbi.nlm.nih.gov/pubmed/29064486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2797
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