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Direct, enantioselective α-alkylation of aldehydes using simple olefins

Although the α-alkylation of ketones has already been established, the analogous reaction using aldehyde substrates has proven surprisingly elusive. Despite the structural similarities between the two classes of compounds, the sensitivity and unique reactivity of the aldehyde functionality has typic...

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Detalhes bibliográficos
Publicado no:Nat Chem
Main Authors: Capacci, Andrew G., Malinowski, Justin T., McAlpine, Neil J., Kuhne, Jerome, MacMillan, David W. C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665178/
https://ncbi.nlm.nih.gov/pubmed/29064486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2797
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