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Enantioselective α-Alkylation of Aldehydes via Photoredox Organocatalysis: Rapid Access to Pharmacophore Fragments from β-Cyanoaldehydes()

The combination of photoredox catalysis and enamine catalysis has enabled the development of an enantioselective α-cyanoalkylation of aldehydes. This synergistic catalysis protocol allows for the coupling of two highly versatile yet orthogonal functionalities, allowing rapid diversification of the o...

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Détails bibliographiques
Publié dans:Angew Chem Int Ed Engl
Auteurs principaux: Welin, Eric R., Warkentin, Alexander A., Conrad, Jay C., MacMillan, David W. C.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548807/
https://ncbi.nlm.nih.gov/pubmed/26130043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201503789
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