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Enantioselective Intramolecular Aldehyde α-Alkylation with Simple Olefins: Direct Access to Homo-Ene Products

A highly selective method for the synthesis of asymmetrically substituted carbocycles and heterocycles from unactivated aldehyde–olefin precursors has been achieved via enantioselective SOMO-catalysis. Addition of a catalytically generated enamine radical cation across a pendent olefin serves to est...

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Autori principali: Comito, Robert J., Finelli, Fernanda G., MacMillan, David W. C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746539/
https://ncbi.nlm.nih.gov/pubmed/23745728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4047312
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