A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation

The Cullin-RING E3 ubiquitin ligases (CRLs) regulate homeostasis of ~20% of cellular proteins and their activation require neddylation of their cullin subunit. Cullin neddylation is modulated by a scaffolding DCN protein through interactions with both the cullin protein and an E2 enzyme such as UBC1...

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Publicado no:Nat Commun
Main Authors: Zhou, Haibin, Lu, Jianfeng, Liu, Liu, Bernard, Denzil, Yang, Chao-Yie, Fernandez-Salas, Ester, Chinnaswamy, Krishnapriya, Layton, Stephanie, Stuckey, Jeanne, Yu, Qing, Zhou, Weihua, Pan, Zhenqiang, Sun, Yi, Wang, Shaomeng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658359/
https://ncbi.nlm.nih.gov/pubmed/29074978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01243-7
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