Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-mediated Cullin Neddylation

We previously reported the discovery, validation, and structure-activity relationships of a series of piperidinyl ureas that potently inhibit the DCN1-UBE2M interaction. We demonstrated that compound 7 inhibits both the DCN1-UBE2M protein-protein interaction and DCN1-mediated cullin neddylation in b...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Hammill, Jared T., Bhasin, Deepak, Scott, Daniel C., Min, Jaeki, Chen, Yizhe, Lu, Yan, Yang, Lei, Kim, Ho Shin, Connelly, Michele C., Hammill, Courtney, Holbrook, Gloria, Jeffries, Cynthia, Singh, Bhuvanesh, Schulman, Brenda A., Guy, R. Kiplin
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5914176/
https://ncbi.nlm.nih.gov/pubmed/29547693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01282
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