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Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M
[Image: see text] The cullin-RING ubiquitin ligases (CRLs) are ubiquitin E3 enzymes that play a key role in controlling proteasomal degradation and are activated by neddylation. We previously reported inhibitors that target CRL activation by disrupting the interaction of defective in cullin neddylat...
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| Publicat a: | J Med Chem |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical Society
2021
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8159160/ https://ncbi.nlm.nih.gov/pubmed/33945681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.1c00035 |
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