Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-mediated Cullin Neddylation

We previously discovered and validated a class of piperidinyl ureas that regulate defective in cullin neddylation 1 (DCN1)-dependent neddylation of cullins. Here, we report preliminary structure-activity relationship studies aimed at advancing our high-throughput screen hit into a tractable tool com...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Hammill, Jared T., Scott, Daniel C., Min, Jaeki, Connelly, Michele C., Holbrook, Gloria, Zhu, Fangyi, Matheny, Amy, Yang, Lei, Singh, Bhuvanesh, Schulman, Brenda A., Guy, R. Kiplin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5898815/
https://ncbi.nlm.nih.gov/pubmed/29547696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01277
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