Targeting latency-associated peptide promotes anti-tumor immunity

Regulatory T cells promote cancer by suppressing anti-tumor immune responses. We found that anti-LAP antibody which targets the latency-associated peptide (LAP)/TGF-β complex on Tregs and other cells enhances anti-tumor immune responses and reduces tumor growth in models of melanoma, colorectal carc...

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Publicat a:Sci Immunol
Autors principals: Gabriely, Galina, da Cunha, Andre P., Rezende, Rafael M., Kenyon, Brendan, Madi, Asaf, Vandeventer, Tyler, Skillin, Nathaniel, Rubino, Stephen, Garo, Lucien, Mazzola, Maria A., Kolypetri, Panagiota, Lanser, Amanda J., Moreira, Thais, Faria, Ana Maria C., Lassmann, Hans, Kuchroo, Vijay, Murugaiyan, Gopal, Weiner, Howard L.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5657397/
https://ncbi.nlm.nih.gov/pubmed/28763794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaj1738
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