MicroRNA-146a limits tumorigenic inflammation in colorectal cancer

Chronic inflammation can drive tumor development. Here, we have identified microRNA-146a (miR-146a) as a major negative regulator of colonic inflammation and associated tumorigenesis by modulating IL-17 responses. MiR-146a-deficient mice are susceptible to both colitis-associated and sporadic colore...

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Pubblicato in:Nat Commun
Autori principali: Garo, Lucien P., Ajay, Amrendra K., Fujiwara, Mai, Gabriely, Galina, Raheja, Radhika, Kuhn, Chantal, Kenyon, Brendan, Skillin, Nathaniel, Kadowaki-Saga, Ryoko, Saxena, Shrishti, Murugaiyan, Gopal
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065171/
https://ncbi.nlm.nih.gov/pubmed/33893298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22641-y
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