Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity

Smad7, a negative regulator of TGF-β signaling, has been implicated in the pathogenesis and treatment of inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis (UC). Here, we found that Smad7 mediates intestinal inflammation by limiting the PDL2/1-PD1 axis in dendr...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Garo, Lucien P., Ajay, Amrendra K., Fujiwara, Mai, Beynon, Vanessa, Kuhn, Chantal, Gabriely, Galina, Sadhukan, Supriya, Raheja, Radhika, Rubino, Stephen, Weiner, Howard L., Murugaiyan, Gopal
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925592/
https://ncbi.nlm.nih.gov/pubmed/31553906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.065
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