Targeting latency-associated peptide promotes anti-tumor immunity

Regulatory T cells promote cancer by suppressing anti-tumor immune responses. We found that anti-LAP antibody which targets the latency-associated peptide (LAP)/TGF-β complex on Tregs and other cells enhances anti-tumor immune responses and reduces tumor growth in models of melanoma, colorectal carc...

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Detalhes bibliográficos
Publicado no:Sci Immunol
Main Authors: Gabriely, Galina, da Cunha, Andre P., Rezende, Rafael M., Kenyon, Brendan, Madi, Asaf, Vandeventer, Tyler, Skillin, Nathaniel, Rubino, Stephen, Garo, Lucien, Mazzola, Maria A., Kolypetri, Panagiota, Lanser, Amanda J., Moreira, Thais, Faria, Ana Maria C., Lassmann, Hans, Kuchroo, Vijay, Murugaiyan, Gopal, Weiner, Howard L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5657397/
https://ncbi.nlm.nih.gov/pubmed/28763794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaj1738
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