Targeting latency-associated peptide promotes anti-tumor immunity

Regulatory T cells promote cancer by suppressing anti-tumor immune responses. We found that anti-LAP antibody which targets the latency-associated peptide (LAP)/TGF-β complex on Tregs and other cells enhances anti-tumor immune responses and reduces tumor growth in models of melanoma, colorectal carc...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Immunol
Main Authors: Gabriely, Galina, da Cunha, Andre P., Rezende, Rafael M., Kenyon, Brendan, Madi, Asaf, Vandeventer, Tyler, Skillin, Nathaniel, Rubino, Stephen, Garo, Lucien, Mazzola, Maria A., Kolypetri, Panagiota, Lanser, Amanda J., Moreira, Thais, Faria, Ana Maria C., Lassmann, Hans, Kuchroo, Vijay, Murugaiyan, Gopal, Weiner, Howard L.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5657397/
https://ncbi.nlm.nih.gov/pubmed/28763794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaj1738
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