Two plant-derived aporphinoid alkaloids exert their antifungal activity by disrupting mitochondrial iron-sulfur cluster biosynthesis

Eupolauridine and liriodenine are plant-derived aporphinoid alkaloids that exhibit potent inhibitory activity against the opportunistic fungal pathogens Candida albicans and Cryptococcus neoformans. However, the molecular mechanism of this antifungal activity is unknown. In this study, we show that...

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Vydáno v:J Biol Chem
Hlavní autoři: Tripathi, Siddharth K., Xu, Tao, Feng, Qin, Avula, Bharathi, Shi, Xiaomin, Pan, Xuewen, Mask, Melanie M., Baerson, Scott R., Jacob, Melissa R., Ravu, Ranga Rao, Khan, Shabana I., Li, Xing-Cong, Khan, Ikhlas A., Clark, Alice M., Agarwal, Ameeta K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633121/
https://ncbi.nlm.nih.gov/pubmed/28821607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.781773
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