Two plant-derived aporphinoid alkaloids exert their antifungal activity by disrupting mitochondrial iron-sulfur cluster biosynthesis

Eupolauridine and liriodenine are plant-derived aporphinoid alkaloids that exhibit potent inhibitory activity against the opportunistic fungal pathogens Candida albicans and Cryptococcus neoformans. However, the molecular mechanism of this antifungal activity is unknown. In this study, we show that...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Biol Chem
मुख्य लेखकों: Tripathi, Siddharth K., Xu, Tao, Feng, Qin, Avula, Bharathi, Shi, Xiaomin, Pan, Xuewen, Mask, Melanie M., Baerson, Scott R., Jacob, Melissa R., Ravu, Ranga Rao, Khan, Shabana I., Li, Xing-Cong, Khan, Ikhlas A., Clark, Alice M., Agarwal, Ameeta K.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2017
विषय:
Metabolism
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633121/
https://ncbi.nlm.nih.gov/pubmed/28821607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.781773
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