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Synthesis and antifungal activities of miltefosine analogs
Miltefosine is an alkylphosphocholine that shows broad-spectrum in vitro antifungal activities and limited in vivo efficacy in mouse models of cryptococcosis. To further explore the potential of this class of compounds for the treatment of systemic mycoses, nine analogs (3a–3i) were synthesized by m...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3760157/ https://ncbi.nlm.nih.gov/pubmed/23891181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.06.096 |
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